| 摘要 |
600240 The disclosure provides quinuclidine compounds of formula I their sterio isomers, and including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the alpha-7 nicotinic acetylcholine receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. Compounds of the disclosure include: (R)-N-(6-(1H-imidazol-1-yl)pyrimidin-4-yl)-4H-1’-azaspiro[oxazole-5,3’-bicyclo[2.2.2]5 octan]-2-amine, (R)-N-(3,4’-Bipyridin-2’-yl)-4H-1’-azaspiro[oxazole-5,3’-bicyclo[2.2.2]octan]-2-amine, And (3R)-N-(6-chloro-5-bromopyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5’-4H-1,3-oxazole]-2’-amine |
