发明名称 |
Recombinant human adenoviralserotype 35, a nucleic acid encoding it. a cell compising nucleic acid and a method |
摘要 |
<p>The serotypes differ in their natural tropism. The adenovirus serotypes 2, 4, 5 and 7 all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes 40 and 41 have a natural affiliation towards the gastrointestinal tract. The serotypes described above, differ in at least capsid proteins (penton-base, hexon), proteins responsible for cell binding (fiber protein), and proteins involved in adenovirus replication. This difference in tropism and capsid protein among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins</p> |
申请公布号 |
IL214413(A) |
申请公布日期 |
2014.04.30 |
申请号 |
IL20110214413 |
申请日期 |
2011.08.02 |
申请人 |
CRUCELL HOLLAND B.V.;ABRAHAM BOUT;MENZO JANS EMCO HAVENGA;RONALD VOGELS |
发明人 |
ABRAHAM BOUT;MENZO JANS EMCO HAVENGA;RONALD VOGELS |
分类号 |
C12N15/09;A61K35/76;A61K48/00;A61P43/00;C07K14/075;C12N5/10;C12N15/34;C12N15/86;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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