发明名称 |
USE OF THE CATHELICIDIN LL-37 PEPTIDE DERIVATIVES THEREOF FOR USE IN TREATING CHRONIC WOUNDS |
摘要 |
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37. |
申请公布号 |
EP1589987(B1) |
申请公布日期 |
2014.04.23 |
申请号 |
EP20040705973 |
申请日期 |
2004.01.28 |
申请人 |
LIPOPEPTIDE AB |
发明人 |
ST HLE-BAECKDAHL, MONA;HEILBORN, JOHAN;CARLSSON, ANDERS;BOGENTOFT, CONNY |
分类号 |
A61P17/02;A61K;A61K9/127;A61K38/00;A61K38/16;C07K14/47;C12N5/00;C12N5/071 |
主分类号 |
A61P17/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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