发明名称 |
Isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen, conjugates and uses thereof |
摘要 |
An isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen (PSMA) preferably in its native form on the surface of tumour cells. A conjugate of the antibody with an active ingredient and modified forms of the antigen-binding antibody fragment are also provided. The complete antibody and the antigen-recognising fragment thereof are used alone or conjugated for the treatment and the diagnosis of tumours or tissues associated to the tumour overexpressing the PSMA antigen, preferably prostatic neoplastic diseases. |
申请公布号 |
US8703918(B2) |
申请公布日期 |
2014.04.22 |
申请号 |
US20090989316 |
申请日期 |
2009.04.22 |
申请人 |
COLOMBATTI MARCO;FRACASSO GIULIO;CINGARLINI SARA;CANEVARI SILVANA;FIGINI MARIANGELA;UNIVERSITA' DEGLI STUDI DI VERONA;FONDAZIONE IRCCS “INSTITUTO NAZIONALE DEI TUMORI” |
发明人 |
COLOMBATTI MARCO;FRACASSO GIULIO;CINGARLINI SARA;CANEVARI SILVANA;FIGINI MARIANGELA |
分类号 |
C07K16/00;A61K39/00;A61K39/395;C12P21/08;G01N33/53 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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