发明名称 |
PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2 |
摘要 |
<p>Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of all-trans" configuration to monoprenyl derivative of menadiol following 1 + 6" synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z' and Z' represent H or one of Z' and Z" represents H and the other represents phenylsulfonyl group -SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.</p> |
申请公布号 |
CA2888010(A1) |
申请公布日期 |
2014.04.17 |
申请号 |
CA20132888010 |
申请日期 |
2013.10.11 |
申请人 |
NATTOPHARMA R&D LTD. |
发明人 |
KRAJEWSKI, KRZYSZTOF;KUTNER, ANDRZEJ;DZIKOWSKA, JADWIGA;GUTOWSKA, JADWIGA;NAPIORKOWSKI, MAREK;WINIARSKI, JERZY;KUBISZEWSKI, MAREK;JEDYNAK, LUKASZ;MORZYCKI, JACEK;WITKOWSKI, STANISLAW;BAJ, ANETA;WALEJKO, PIOTR |
分类号 |
C07C45/27;C07C49/683;C07C315/04;C07C317/18 |
主分类号 |
C07C45/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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