NOVEL SINGLE NUCLEOTIDE VARIATIONS MARKER FOR WHITE FUR/HAIR TRAITS

摘要

The present invention relates to a novel single nucleotide variations (SNVs) marker for white fur/hair traits, and, more specifically, relates to an SNVs (single nucleotide variations) marker which is specific to white fur/hair traits including variations in Arg87Gln in a tyrosinase (TYR) amino acid sequence and variations in Thr509Ala in a dopachrome tautomerase (DCT) amino acid sequence inherent in white lions having white fur traits; discovered by subjecting individuals of various species to inter-species sequence comparative analysis (interspecific sequence comparison) of the amino acid sequences of TYR and DCT, which are enzymes associated with melamine formation. The SNVs marker according to the present invention provides genetic information relating to white fur/hair traits in animals and thus can be widely used, for example in species improvement via animal trait adjustment not to mention in the field of developing drugs from new target candidates for various albinism conditions including systemic albinism (oculocutaneous albinism) and the like.