A PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE COMPRISING MYAGROPSIS MYAGROIDES EXTRACTS OR FRACTION THEREOF AS AN EFFECTIVE INGREDIENT

摘要

The present invention relates to a composition for treating or preventing inflammatory diseases. The present invention provides a pharmaceutical composition for preventing or treating inflammatory diseases, which comprises a Myagropsis myagroides extract or a fraction of the extract as an active ingredient. The Myagropsis myagroides extract or the fraction thereof does not contain known existing fucoxanthin but controls the generation of nitrogen monoxide (NO), prostaglandin E_2 (PGE_2) and inflammatory cytokines and also controls the expression of iNOS and COX-2 effectively so that the pharmaceutical composition can be used usefully for preventing and treating inflammatory diseases. [Reference numerals] (AA) Myagropsis myagroides; (BB) Sun drying; (CC) Extraction by reflux condensing (Repeat three times); (DD) Powder; (EE) Extract; (FF) Vaccum filtration; (GG) Vacuum rotating concentration/40°C (solvent removal); (HH) Crude extract; (II) Myagropsis myagroides crude extract; (JJ) Organic solvent soluble fractioning (Repeat 3-4 times); (KK) n-hexane soluble fraction; (LL,NN,PP,RR) Water soluble fraction; (MM) Dichloromethane soluble fraction; (OO) Ethyl acetate soluble fraction; (QQ) n-butanol soluble fraction