发明名称 |
IgE antibodies for the treatment of cancer |
摘要 |
The present invention provides monoclonal IgE antibodies comprising Fc epsilon (ε) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA). |
申请公布号 |
US8697079(B2) |
申请公布日期 |
2014.04.15 |
申请号 |
US201213372557 |
申请日期 |
2012.02.14 |
申请人 |
PENICHET MANUEL L.;SCHULTES BIRGIT C.;NICODEMUS CHRISTOPHER F.;DANIELS TRACY R.;HELGUERA GUSTAVO;RODRIGUEZ JOSE A.;QUEST PHARMA TECH INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PENICHET MANUEL L.;SCHULTES BIRGIT C.;NICODEMUS CHRISTOPHER F.;DANIELS TRACY R.;HELGUERA GUSTAVO;RODRIGUEZ JOSE A. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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