COMPOSITIONS, DEVICES, SYSTEMS, AND METHODS FOR USING NANOPORE

摘要

PROBLEM TO BE SOLVED: To provide devices and methods that can detect and control an individual polymer in a mixture to be acted upon by another compound, such as an enzyme, in a nanopore.SOLUTION: The devices and methods are also used to quickly (greater than about 50 Hz) determine the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.