Process for the Production of 3-Oxo-pregn-4-ene-21,17-carbolactones by the Metal-Free Oxidation of 17-(3-Hydroxypropyl)-3,17-dihydroxyandrostanes

摘要

This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula II
as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula III
by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula I In addition, the invention relates to the dichloromethane hemisolvate of 6²,7²;15²,16²-dimethylene-3-oxo-17±-pregnan-5²-ol-21,17-carbolactone (IV) as such as well as to a process for the production of drospirenone.