发明名称 |
CYTOKINE BIOMARKERS AS PREDICTIVE BIOMARKERS OF CLINICAL RESPONSE FOR GLATIRAMER ACETATE |
摘要 |
A method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of determining whether the human subject is a glatiramer acetate responder by evaluating a biomarker selected from the group consisting of IL-17 concentration, TNF-α concentration, IL-2 concentration and IFN-γ concentration, or a combination thereof, in the blood of the human subject and administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the human subject only if the human subject is identified as a glatiramer acetate responder. |
申请公布号 |
EP2627669(A4) |
申请公布日期 |
2014.04.09 |
申请号 |
EP20110833199 |
申请日期 |
2011.10.10 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
KASPER, LLOYD, H.;SMITH, JACQUELINE, Y. |
分类号 |
C07K14/47;A61K38/00;A61K38/06;A61K38/07;A61P19/08;G01N33/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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