COMPOSTO, PROCESSO PARA PREPARAR E PARA GERAR ANÁLOGO DE MACBECINA, ANÁLOGO DE MACBECINA, COMPOSIÇÃO FARMACÊUTICA, USO DO ANÁLOGO DE MACBECINA, E, CEPA ENGENHEIRADA.

摘要

The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.