Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
申请公布号
HK1140139(A1)
申请公布日期
2014.04.04
申请号
HK20100106383
申请日期
2010.06.30
申请人
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY;THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION