METHOD FOR DIAGNOSING IGG4 RELATED DISEASES

摘要

The invention provides a method of determining the risk of suffering from or developing an IgG4-related systemic disease in a subject comprising the steps of determining in a biological sample from said subject the number and/or frequency of IgG4 positive BCR clones, and determining the risk of suffering from or developing an IgG4- related systemic disease based on said number of IgG4 positive BCR clones, wherein an increase of said number of IgG4 positive BCR clones and/or a higher frequency of at least one IgG4 positive BCR clone compared to a healthy control indicates an increased risk. In a preferred embodiment, said increased risk is indicated when at least 0.5% of the total number of BCR clones is an IgG4 positive BCR clone.