发明名称 |
ENZYME AND RECEPTOR MODULATION |
摘要 |
Covalent conjugates of anα,α-disubstituted glycine ester and a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid and theα,α-disubstituted glycine ester is conjugated to the modulator at a position remote from the binding interface between the inhibitor and the target enzyme or receptor pass into cells and the active acid hydrolysis product accumulates within the cells. |
申请公布号 |
US2014088159(A1) |
申请公布日期 |
2014.03.27 |
申请号 |
US201314091522 |
申请日期 |
2013.11.27 |
申请人 |
DRUMMOND ALAN HASTINGS;DAVIDSON ALAN HORNSBY;MOFFAT DAVID FESTUS CHARLES;DONALD ALASTAIR DAVID GRAHAM;DAVIES STEPHEN JOHN;CHROMA THERAPEUTICS LTD. |
发明人 |
DRUMMOND ALAN HASTINGS;DAVIDSON ALAN HORNSBY;MOFFAT DAVID FESTUS CHARLES;DONALD ALASTAIR DAVID GRAHAM;DAVIES STEPHEN JOHN |
分类号 |
C07D213/73;C12Q1/48 |
主分类号 |
C07D213/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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