发明名称 |
Manufacturing process for tiotropium bromide |
摘要 |
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I). |
申请公布号 |
US8680297(B2) |
申请公布日期 |
2014.03.25 |
申请号 |
US201113200975 |
申请日期 |
2011.10.06 |
申请人 |
SOUKUP MILAN;DRUG PROCESS LICENSING ASSOC., LLC |
发明人 |
SOUKUP MILAN |
分类号 |
C07D409/14 |
主分类号 |
C07D409/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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