<p>The invention is directed to delivery medical devices that enable consistent "on-demand" delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.</p>
申请公布号
CA2883903(A1)
申请公布日期
2014.03.13
申请号
CA20132883903
申请日期
2013.09.05
申请人
W.L. GORE & ASSOCIATES, INC.
发明人
CAMPBELL, CAREY V.;CLEEK, ROBERT L.;CULLY, EDWARD H.;HEICKSEN, PETER;HOLLAND, THERESA A.;KRANZLER, THANE L.;LI, MEI;STEINHAUS, BRUCE M.;TRAPP, BENJAMIN M.;TRIEBES, THOMAS G.;VONESH, MICHAEL J.