发明名称 |
Methods for determining cancer resistance to histone deacetylase inhibitors |
摘要 |
[00153] Described herein are methods and compositions for determining whether a particular cancer is resistant to or susceptible to a histone deacetylase inhibitor or to histone deacetylase inhibitors. The methods include analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are methods and compositions for increasing the likelihood of a therapeutically effective treatment in a patient, comprising an analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are isolated populations of nucleic acids derived from a cancer sensitive to or resistant to a histone deacetylase inhibitor. Further described are kits and indications that are used in conjunction with the aforementioned methods and compositions. |
申请公布号 |
AU2008210421(B2) |
申请公布日期 |
2014.03.13 |
申请号 |
AU20080210421 |
申请日期 |
2008.01.30 |
申请人 |
PHARMACYCLICS, INC. |
发明人 |
BALASUBRAMANIAN, SRIRAM;BUGGY, JOSEPH J. |
分类号 |
A61K49/00;C12Q1/68;G01N33/574 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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