发明名称 |
CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE |
摘要 |
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the alphaKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. |
申请公布号 |
WO2013184960(A3) |
申请公布日期 |
2014.03.13 |
申请号 |
WO2013US44592 |
申请日期 |
2013.06.06 |
申请人 |
NEW YORK UNIVERSITY;MOHAMMADI, MOOSA;GOETZ, REGINA |
发明人 |
MOHAMMADI, MOOSA;GOETZ, REGINA |
分类号 |
A61K38/18;A61K38/00;A61K38/24;C07K5/00;C07K14/50;C12P21/04 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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