Method and process for preparation and production of deuterated Omega-diphenylurea

摘要

Methods and processes for preparation and production of deuterated omega-diphenylurea are disclosed. Especially, a kind of deuterated omega-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.