UTILIZAÇÃO DA 10-[(3R)-1-AZABICICLO[2.2.2.]OCT-3-ILMETIL]-10H-FENOTIAZIN A PARA O PREPARO DE UM MEDICAMENTO QUE EXERCE UMA INIBIÇÃO SELETIVA DOS RECEPTORES MUSCARÍNICOS M1, M2, M3

摘要

Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (I) and its salts for the manufacture of a medicament to prevent or treat disorders, diseases and/or pathologies by selectively inhibiting of muscarinic M1 receptor, muscarinic M2 receptor and muscarinic M3 receptor, is claimed. - ACTIVITY : Uropathic; Antibacterial; Fungicide. - MECHANISM OF ACTION : Muscarinic M1 receptor inhibitor; Muscarinic M2 receptor inhibitor; Muscarinic M3 receptor inhibitor. The effect of (I) to inhibit the muscarinic M1 receptor was tested in Chinese hamster ovary cells using in vitro assay. The results showed that (I) exhibited an IC 5 0 value of 1.6 nM.