| 发明名称 |
METHOD FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH AZITHROMYCIN IN ADMA-LIKE GESTOSIS MODEL IN EXPERIMENT |
| 摘要 |
FIELD: medicine.SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 7 days. That is followed by the intragastric introduction of azithromycin 30 mg/kg once a day in the setting of the model above from 14to 20day of pregnancy.EFFECT: method provides the manifested endothelial dysfunction correction in the special pathogenesis environment in the pregnant females in a combination with eliminating acute infectious diseases or aggravated chronic infectious processes that can also lead to the formation of gestosis.1 ex |
| 申请公布号 |
RU2507595(C2) |
申请公布日期 |
2014.02.20 |
| 申请号 |
RU20120108545 |
申请日期 |
2012.03.07 |
| 申请人 |
FEDERAL'NOE GOSUDARSTVENNOE AVTONOMNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "BELGORODSKIJ GOSUDARSTVENNYJ NATSIONAL'NYJ ISSLEDOVATEL'SKIJ UNIVERSITET" |
发明人 |
POKROVSKIJ MIKHAIL VLADIMIROVICH;POKROVSKAJA TAT'JANA GRIGOR'EVNA;KOCHKAROV VLADIMIR ISKHAKOVICH;KOROKIN MIKHAIL VIKTOROVICH;GUDYREV OLEG SERGEEVICH;ARUSTAMOVA ANNA ALEKSANDROVNA;ZHERNAKOV EVGENIJ VLADISLAVOVICH;GOLOVCHENKO IGOR' OLEGOVICH;GUREEV VLADIMIR VLADIMIROVICH;POLJANSKAJA OKSANA SERGEEVNA;TSYBUL'SKIJ IGOR' VALER'EVICH;MOSTOVOJ ALEKSANDR SERGEEVICH |
| 分类号 |
G09B23/28;A61P9/08;A61P15/06 |
主分类号 |
G09B23/28 |
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