发明名称 |
Bisphosphonate-Prostatic Acid Phosphatase Inhibitor Conjugates To Treat Prostate Cancer Bone Metastasis |
摘要 |
The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid. |
申请公布号 |
US2014045797(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
US201314055313 |
申请日期 |
2013.10.16 |
申请人 |
LEHIGH UNIVERSITY;MOUNT SINAI SCHOOL OF MEDICINE |
发明人 |
KIRSCHENBAUM ALEXANDER;LEVINE ALICE C.;REGEN STEVEN L.;JANOUT VACLAV |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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