发明名称 |
METHODS AND KITS FOR SCREENING PATIENTS WITH A CANCER |
摘要 |
<p>A method for screening patients with a cancer comprising i) determining in a tumor sample obtained from a patient an expression level ELA1 - ELAn of one or several genes GA1 - GAn representative of human adaptive immune response and an expression level ELI1 - ELIn of one or several genes Gl1 - GIn representative of human immunosuppressive response, ii) comparing the expression levels ELA1 - ELAn and ELI1 - ELIn determined at step i) with predetermined reference values ELRA1 - ELRAn and ELRI1 - ELRIn selected such as said predetermined reference values separate a panel of patients with a cancer into two groupings according to the expression level of said genes and to survival of patients according to Kaplan Meier curves analyses and associated logrank p values iii) concluding whether the patient has a good (level higher than the predetermined reference value) or a bad (level lower than the predetermined reference value) adaptive immune response and a good or a bad immunosuppressive response, optionally further comprising a step of concluding that a patient would or would not advantageously receive an antitumoral treatment, a kit comprising components for implementing step i) and a chemotherapeutic agent, an immunotherapeutic agent or a radiotherapeutic agent for use in the treatment of a cancer patient who is considered as responder to antitumoral treatment according to the method.</p> |
申请公布号 |
CA2881389(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
CA20132881389 |
申请日期 |
2013.08.05 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE PARIS DESCARTES;ASSISTANCE PUBLIQUE HOPITAUX DE PARIS |
发明人 |
GALON, JEROME;PAGES, FRANCK;MLECNIK, BERNHARD;BINDEA, GABRIELA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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