QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS

摘要

Provided herein are novel sirtuin-modulating compoundsand methods of use thereof The sirtuin-modulating compounds may beused for increasing the lifespan of a cell, and treating and/orpreventing a wide variety of diseases and disorders including, forexample, diseases or disorders related to aging or stress, diabetes,obesity, neurodegenerative diseases, cardiovascular disease, bloodclotting disorders, inflammation, cancer, and/or flushing as well asdiseases or disorders that would benefit from increased mitochondrialactivity. Also provided are compositions comprising asirtuin-modulating compound in combination with another therapeuticagent.