POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION
摘要
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
申请公布号
EP1562971(B1)
申请公布日期
2014.02.12
申请号
EP20030768647
申请日期
2003.11.04
申请人
ISIS PHARMACEUTICALS, INC.
发明人
ALLERSON, CHARLES;BHAT, BALKRISHEN;ELDRUP, ANN, B.;MANOHARAN, MUTHIAH;GRIFFEY, RICHARD;BAKER, BRENDA, F.;SWAYZE, ERIC, E.