| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compound of formula Iin which Rrepresents halogen, methoxy group or cyano group; each of Yand Yrepresents CH, and one or two from U, V, W and X represent N, and each remaining one represents CH, or in case X, cam also represent CR, or Rrepresents halogen; A represents CHCH(OH), CHCH(NH), CH(OH)CH(NH) or CH(NH)CH, B represents CHCH, CHNH or CONH, and D represents CH, or A represents CH(OH)CH, and B represents CHNH, N(R)CO or CONH, and D represents CH, or B represents N(R)CH, and D represents CH(OH), or A represents CH(OH)CH(OH), B represents CHNH or CONH and D represents CH, or A represents CHCH, and B represents CHCH, CHNR, NHCO, CONR, CHO, COCHor CHCHNH, and D represents CH, or B represents CHNH, and D represents CO, or A also represents CHCH, B represents NRCHand D represents CH(OH), or A represents CH=CH, B represents CHNRor CONR, and D represents CH, or A represents C?C, B represents CHNH and D represents CO, or A represents COCH, B represents CONH and D represents CH, or A represents CHN(R), and B represents CHCH, a D represents CH, or B represents CHCH(OH), a D represents CH(OH), or A represents NHCH, and B represents CHNH, a D represents CH, or B represents CHNH, a D represents CO, or A represents NHCO, B represents CH(R)NH or CHCH, and D represents CH, or A represents OCH, B represents CH=CH or CONH, and D represents CH; Rrepresents (C-C)alkyl; Rrepresents hydrogen; Rrepresents hydrogen, CO-(CH)-COOR, (CH)-COOR, (C-C)acyl or amino(C-C)alkyl, or also Rrepresents (C-Calkyl, which can be one or two times substituted with hydroxygroup, p stands for integer number from 1 to 4, and Rrepresents hydrogen or (C-C)alkyl; Rrepresents hydrogen or (C-C)alkyl; Rrepresents hydrogen; Rrepresents hydrogen or (C-C)acyl; Rrepresents hydrogen or (C-C)alkyl; Rrepresents hydrogen or (C-C)alkyl, which can be one or two times substituted with group, independently selected from hydroxygroup and aminogroup, Rrepresents hydrogen or (C-C)alkyl; E represents one of the following groups (a-a1)where Z represents CH or N, and Q represents O or S, or E represents phenyl group, which is one or two times substituted in meta- and/or para-position with substituents, each of which is independently selected from group, including halogen, (C-C)alkyl and trifluoromethyl; or pharmaceutically acceptable salt of such compound. Formula I compound or its pharmaceutically acceptable salt is applied for obtaining medication or pharmaceutical composition for prevention or treatment of bacterial infection.EFFECT: derivatives of oxazolidine antibiotics for obtaining medication for treatment of bacterial infections.15 cl, 2 tbl, 214 ex |
