AN IMPROVED PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE

摘要

The present invention relates to an improved process for the preparation of 1-methyl-2- [N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl- carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide methanesulfonate salt (Dabigatran etexilate mesylate ). Further, the present invention provides a process for purification of Dabigatran etexilate mesylate. Further, the present invention provides provide a process for the preparation of 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N- (2-ethoxy carbonyl ethyl)-amide of formula (VI) an intermediate of Dabigatran.