发明名称 |
Combination therapy for treatment of Multiple sclerosis |
摘要 |
<p>The present invention relates to a method of treating MS in a human patient in need of such treatment and comprises administering to said patient a combination therapy in a single oral dosage form (e.g. a tablet or capsule) of dimethylfumarate and one agent selected from teriflunomide (or its prodrug leflunomide), fingolimod and laquinimod. This combination is more effective than the single agents alone and/or has reduced side effects and better tolerability than the single agents alone and/or can be given in a reduced frequency. Moreover, the present invention is directed to a pharmaceutical composition suitable for the oral treatment of multiple sclerosis consisting of dimethylfumarate and one agent selected from teriflunomide, fingolimod and laquinimod as active ingredients and one or more pharmaceutically acceptable excipients.</p> |
申请公布号 |
EP2692344(A1) |
申请公布日期 |
2014.02.05 |
申请号 |
EP20120187939 |
申请日期 |
2012.10.10 |
申请人 |
FORWARD PHARMA A/S |
发明人 |
TERWEY DR. MED., THEIS;RUPP DR., RONALD;ANDERSEN, PEDER M. |
分类号 |
A61K31/215;A61K9/00;A61K31/137;A61K31/275;A61K31/47;A61P29/00 |
主分类号 |
A61K31/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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