| 摘要 |
<p>The present invention provides a way to treat cancer by modulating JMJD4 activity. The invention also relates to assays for monitoring activity of JMJD4 activities, in particular, to assays for identifying modulators of JMJD4 activities. The invention further relates to assays to monitor the lysyl hydroxylase activity of JMJD4 on its substrate, the translation termination protein eRFl. The invention also enables the introduction of hydroxylysyl residues into peptides and proteins. The invention further provides a way to modulate translation termination and hence to stimulate readthrough of nonsense mutations associated with disease.</p> |
