FUSION GENE OF CEP55 GENE AND RET GENE

摘要

The purpose of the present invention is to identify a gene that can serve as a measure for the prognosis of the effectiveness of a drug-using therapy in cancer, and to provide a novel method for predicting the effectiveness of a drug-using therapy employing the gene as a target. An in-frame fusion transcript of CEP55 gene and RET gene is identified by the transcriptome sequencing of diffuse-type gastric cancer. It is found that this gene fusion induces the activation of RET protein and can transform a cell into a cancer cell. It is demonstrated that a RET tyrosine kinase inhibitor can inhibit the activation of RET protein and the transformation into a cancer cell both of which can be induced by the gene fusion. Thus, it is found that a therapy using a RET tyrosine kinase inhibitor is effective for a patient in which the gene fusion is detected.