SLOW INTRAVENTRICULAR DELIVERY

摘要

PROBLEM TO BE SOLVED: To provide a method to treat neurological diseases, including lysosomal storage diseases.SOLUTION: The treatment method uses intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. The method delivers an agent to a patient's brain, wherein the method comprises administering the agent to the patient via a lateral ventricle of the brain at a rate such that the administration of a single dose consumes more than two hours. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain.