HPLC FRIT FILTER ASSEMBLY

摘要

An apparatus and method for creating a high pressure chromatography frit filter assembly (58b1) is described. The frit (e.g., 64,65) is positioned in bondable contact with a polymer ring (58b) and then the frit is subject to inductive or targeted heating to cause the frit material to heat the adjacent polymer ring from the inside out. The heated polymer liquefies and flows into and past one or more narrowing locations (98a,b,c,d) in the pore passageway extending from the surface (64a) of the frit to an infusion depth (96), which provides previously unachieved secure mechanical engagement and adherence and resistance to pressure blow by (break through) and prevents the flow of contaminants between the edge of the frit and the facing edge of the polymer ring in a high pressure or ultra-high pressure chromatography system, where inlet pressures in the range of pressures up to 18,000 PSI are expected.