发明名称 |
METHODS OF PRODUCTION OF PRODUCTS OF METABOLIC PATHWAYS |
摘要 |
A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase (crtI) and a first transcriptional regulatory sequence; (ii) a polynucleotide which encodes Beta-lycopene cyclase (lcy-B) and a second transcriptional regulatory sequence; (iii) a polynucleotide which encodes Beta-carotene ketolase (crtW) and a third transcriptional regulatory sequence; and wherein the first, second and third regulatory sequence are selected such that the expression of the Icy-B and the crtW is greater than a level of expression of the crtI. Methods of generating astaxanthin using the plurality of polynucleotide are also disclosed as well as bacterial cells comprising high levels of astaxanthin. |
申请公布号 |
WO2014013489(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
WO2013IL50606 |
申请日期 |
2013.07.17 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
MILO, RON;ZELCBUCH, LIOR;ANTONOVSKY, NIV |
分类号 |
C12N1/21;C12N15/52;C12N15/67;C12P23/00 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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