发明名称 |
MEASLES VIRUSES WITH REDUCED SUSCEPTIBILITY TO NEUTRALIZATION |
摘要 |
This document provides methods and materials for making and using measles viruses having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by monoclonal anti-measles virus antibodies and/or serum from measles virus vaccinees). For example, H polypeptides having a reduced ability of being recognized by anti-measles virus antibodies that were generated against a wild-type measles virus or a pre-existing measles virus vaccine such as MV-Edm as compared to a wild-type measles virus H polypeptide or the H polypeptide of MV-Edm are provided. |
申请公布号 |
US2014024100(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
US201313946430 |
申请日期 |
2013.07.19 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
RUSSELL STEPHEN JAMES;LECH PATRYCJA |
分类号 |
C07K14/005;C12N7/00 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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