The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
申请公布号
EP2686307(A1)
申请公布日期
2014.01.22
申请号
EP20120709616
申请日期
2012.03.15
申请人
F.HOFFMANN-LA ROCHE AG;SIENA BIOTECH S.P.A.
发明人
GABELLIERI, EMANUELE;GUBA, WOLFGANG;HILPERT, HANS;MAUSER, HARALD;MAYWEG, ALEXANDER V.;ROGERS-EVANS, MARK;ROMBACH, DIDIER;THOMAS, ANDREW;WOLTERING, THOMAS;WOSTL, WOLFGANG
