9-Bromo-hexahydro- and octahydro-indolo[2,3 a]quinolizines and use for increasing blood circulation

摘要

New salts of the formula XIIIa and XIIIb are disclosed <IMAGE> XIIIa <IMAGE> XIIIb wherein R2, R3 and R5 are each C1 to C6 alkyl and A- is an anion of a pharmaceutically acceptable acid. Furthermore new compounds of the formula XIVa and XIVb are disclosed: <IMAGE> XIVa <IMAGE> XIVb wherein R2 and R3 are as defined above. The new salts and compounds are intermediates in the preparation of 10-bromo-vincaminic acid esters. In addition the new salts and compounds have the ability to increase blood circulation and to decrease blood flow resistance in an animal subject while at the same time maintaining a steady pulse rate and blood pressure.