发明名称 |
MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS |
摘要 |
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species. |
申请公布号 |
CA2878640(A1) |
申请公布日期 |
2014.01.16 |
申请号 |
CA20132878640 |
申请日期 |
2013.07.12 |
申请人 |
ZYMEWORKS, INC. |
发明人 |
D'ANGELO, IGOR EDMONDO PAOLO;NG, GORDON YIU KON;DIXIT, SURJIT BHIMARAO;SANCHES, MARIO |
分类号 |
C07K14/76;C07K16/00 |
主分类号 |
C07K14/76 |
代理机构 |
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