发明名称 USE OF D-SERINE DERIVATIVES FOR THE TREATMENT OF ANXIETY DISORDERS
摘要 Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias, wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R8; R1 is chosen from: alkyl or haloalkyl; R2 is chosen from: H, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7; R3, R4 and R5 are independently chosen from: H or alkyl; R6 and R7 are independently chosen from: H or alkyl; and R8 is chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7.
申请公布号 US2014018549(A1) 申请公布日期 2014.01.16
申请号 US201313870819 申请日期 2013.04.25
申请人 NPS PHARMACEUTICALS, INC.;NPS PHARMACEUTICALS, INC. 发明人 HIGGINS GUY;SLASSI ABDELMALIK;ISAAC METHVIN
分类号 C07D333/22;C07C233/11;C07C233/15;C07C233/51;C07C271/22;C07C311/46 主分类号 C07D333/22
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