发明名称 |
Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene |
摘要 |
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has a flattened structure as a result of the position of at least two exocyclic bonds. |
申请公布号 |
AU2012252024(A1) |
申请公布日期 |
2014.01.09 |
申请号 |
AU20120252024 |
申请日期 |
2012.05.07 |
申请人 |
KONINKLIJKE PHILIPS N.V. |
发明人 |
ROBILLARD, MARC STEFAN;LUB, JOHAN;ROSSIN, RAFFAELLA;VAN DEN BOSCH, SANDRA MARTINA;VERSTEEGEN, RONNY MATHIEU |
分类号 |
A61K51/04;A61K47/48 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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