| 发明名称 |
CELLS, CELL LINES AND NON-HUMAN ANIMAL MODEL FOR DETERMINING THERAPEUTIC AGENTS |
| 摘要 |
<p>The present invention relates to differentiated isolated mesenchymal stem cells having an osteogenic progenitor, which are genetically modified by deleting the sequences or a fragment of the sequences that code for protein p53 and protein Rb. The cells described in the present invention also have the ability to generate osteosarcoma-type tumours in vivo. The present invention also relates to the cell populations and lines, and to a non-human animal model in which said osteosarcoma-like stem cells have been implanted. Moreover, the present invention relates to the method for obtaining said cells and to the uses thereof, preferably for screening for agents that can be used in the treatment and/or prevention of sarcoma.</p> |
| 申请公布号 |
WO2014001596(A1) |
申请公布日期 |
2014.01.03 |
| 申请号 |
WO2013ES70444 |
申请日期 |
2013.06.28 |
| 申请人 |
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD |
发明人 |
RUBIO AMADOR, RUTH;RODRIGUEZ GONZALEZ, RENE;MENENDEZ BUJAN, PABLO |
| 分类号 |
C12N5/10;C12N5/0775 |
主分类号 |
C12N5/10 |
| 代理机构 |
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