METHODS FOR PRODUCING THREE-DIMENSIONAL PHYSIOLOGICALLY RELEVANT IMMUNE TISSUE SYSTEMS UNDER LOW FLUID SHEAR CONDITIONS

摘要

Methods of producing a three-dimensional, physiologically relevant immune tissue system, including culturing an immune cell and at least one other cell type separately; placing immune cell and the at least one other cell type in a low fluid shear environment for a time period; and co-culturing the cells under conditions selected to produce a three-dimensional immune tissue system with physiologically relevant characteristics.