发明名称 |
DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS |
摘要 |
Provided herein are compounds of the formula (I): were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome. |
申请公布号 |
EP2350311(B1) |
申请公布日期 |
2013.12.25 |
申请号 |
EP20090826537 |
申请日期 |
2009.10.27 |
申请人 |
MADRIGAL PHARMACEUTICALS, INC. |
发明人 |
BOLIN, DAVID, R.;CHEUNG, ADRIAN, WAI-HING;HAMILTON, MATTHEW, MICHAEL;MARCOPULOUS, NICHOLAS;MCDERMOTT, LEE, APOSTLE;QIAN, YIMIN |
分类号 |
C07D213/82;A61K31/015;A61K31/4427;A61P3/00;C07D213/75;C07D277/46;C07D277/82;C07D295/155;C07D295/185;C07D295/205;C07D333/54;C07D401/04;C07D401/12;C12Q1/48 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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