| 摘要 |
Preparing 2,2-difluoroethylamine-derivatives comprises hydrogenating 2,2-difluoroethylimine-derivative (IV) to the corresponding 2,2-difluoroethylamine-derivative (III). Preparing 2,2-difluoroethylamine-derivatives comprises hydrogenating 2,2-difluoroethylimine-derivative of formula (A-CH 2=N-CH 2-C(F) 2) (IV) to the corresponding 2,2-difluoroethylamine-derivative of formula (A-CH 2-NH-CH 2-C(F) 2) (III). A : pyrid-2-yl, pyrid-4-yl or pyrid-3-yl (all optionally substituted by F, Cl, Br, CH 3, CF 3or CF 3O (at 6th position)) or pyridazin-3-yl (optionally substituted by Cl or CH 3(at 6th position)), and pyrazin-3-yl, 2-chloropyrazin-5-yl or 1,3-thiazol-5-yl (all optionally substituted by Cl or CH 3(at 2nd position)), or pyrimidinyl, pyrazolyl, thiophenyl, oxazolyl, isoxazolyl, 1,2,4-oxadiazolyl, isothiazolyl, 1,2,4-triazolyl or 1,2,5-thiadiazolyl (all optionally substituted by F, Cl, Br, CN, NO 2, 1-4C-alkyl (optionally substituted by F and/or Cl), 1-3C-alkylthio (optionally substituted by F and/or Cl), 1-3C-alkylsulfonyl (optionally substituted by F and/or Cl)) or substituted pyridine moiety of formula (A1); X : halo, alkyl or haloalkyl; and Y 1>halo, alkyl, haloalkyl, haloalkoxy, azido or cyano-group. Independent claims are included for: (1) preparing 2,2-difluoroethylimine-derivative of formula (IV) comprising reacting a carbonyl compound of formula (A-C(=O)-H) (VI) with 2,2-difluoroethylamine; and (2) the 2,2-difluoroethylimine-derivative (IV). [Image] |
