NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS

摘要

FIELD: chemistry.SUBSTANCE: invention relates to novel pyrrole compounds of formula I or pharmaceutically acceptable salts thereof:I, where: Ar denotes phenyl, thiophenyl; Rdenotes imidazolyl, imidazolyl substituted with C-Calkyl, chlorine, bromine, fluorine, hydroxy group, methoxy group; Rdenotes H, CH, Cl, F, OH, OCH, OCH, propoxy group, carbamoyl, dimethylamino group, NH, formamide group, CF; X denotes CO and SO. The compounds inhibit S-nitrosoglutathione reductase (GSNOR).EFFECT: using the compound to produce a pharmaceutical composition and for treating asthma.17 cl, 1 tbl, 14 dwg, 4 ex