发明名称 |
AGENT FOR IMPARTING PH DEPENDANT CATIONIC PROPERTY TO LIPID MEMBRANE STRUCTURE, THE LIPID MEMBRANE STRUCTURE GIVEN THE PH DEPENDANT CATIONIC PROPERTY THEREBY, AND PRODUCTION METHOD FOR LIPID MEMBRANE STRUCTURE |
摘要 |
PROBLEM TO BE SOLVED: To provide an agent which has YSK05 as an effective component and imparts a pH dependant cationic property to a lipid membrane structure, to provide the lipid membrane structure given the pH dependent cationic property thereby, and to provide a production method for the lipid membrane structure.SOLUTION: An effective component of an agent is 1-methyl-4,4-bis[(9Z, 12Z)-octadeca-9,12-dien-1-yloxy]piperidine. A lipid structure impart a pH dependant cationic property to a lipid structure without giving an influence to a property such as a particle diameter and PDI of the lipid structure, improves membrane fusing performance with a biomembrane as the pH decreases, effectively involves a substance such as a siRNA and a drug, and also protects the involved substance from decomposing, etc. in a serum to stably hold it. |
申请公布号 |
JP2013245190(A) |
申请公布日期 |
2013.12.09 |
申请号 |
JP20120119521 |
申请日期 |
2012.05.25 |
申请人 |
BIOMEDCORE INC;HARASHIMA HIDEYOSHI;HATAKEYAMA HIROTO;SATO YUSUKE;HYODO MAMORU;SAKURAI YU;AKITA HIDETAKA |
发明人 |
HARASHIMA HIDEYOSHI;HATAKEYAMA HIROTO;SATO YUSUKE;HYODO MAMORU;SAKURAI YU;AKITA HIDETAKA |
分类号 |
A61K47/22;A61K9/127;A61K31/7105;A61K47/24;A61K47/28;A61K47/34;A61K48/00;A61P43/00;C12N15/09 |
主分类号 |
A61K47/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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