发明名称 |
Method for administering an NMDA receptor antagonist to a subject |
摘要 |
Compositions and methods for administering memantine to a subject are provided. In particular, a solid pharmaceutical composition in a unit dosage form for once daily oral administration is provided. The compositions comprises an extended release formulation of 22.5 mg to 33.75 mg memantine, or a pharmaceutically acceptable salt thereof, wherein administration of a dose of the composition to a human subject provides a mean plasma memantine concentration profile characterized by a change in memantine concentration as a function of time (dC/dT) that is less than 50% of the dC/dT provided by the same quantity of an immediate release form of memantine, determined in a time period between 0 hours to 6 hours after administration of memantine, and wherein dC/dT is measured in a single-dose human PK study. Methods of treating dementia, in particular Alzheimer's diseases, using the compositions are provided. |
申请公布号 |
US8598233(B2) |
申请公布日期 |
2013.12.03 |
申请号 |
US201313751876 |
申请日期 |
2013.01.28 |
申请人 |
ADAMAS PHARMACEUTICALS, INC.;ADAMAS PHARMACUETICALS, INC. |
发明人 |
WENT GREGORY T.;FULTZ TIMOTHY J.;MEYERSON LAURENCE R. |
分类号 |
A61K9/00;A01N47/28;A61K31/17 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|