发明名称 |
CONJUGATES FOR THE TREATMENT OF MESOTHELIOMA |
摘要 |
The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.
|
申请公布号 |
US2013315856(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
US201313750682 |
申请日期 |
2013.01.25 |
申请人 |
BORDIGNON CLAUDIO;LAMBIASE ANTONIO;MOLMED S.P.A |
发明人 |
BORDIGNON CLAUDIO;LAMBIASE ANTONIO |
分类号 |
C07K14/525;C07K7/06 |
主分类号 |
C07K14/525 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|