发明名称 |
Fucosylation-deficient cells |
摘要 |
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 21 1, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided. |
申请公布号 |
AU2010256753(B2) |
申请公布日期 |
2013.11.28 |
申请号 |
AU20100256753 |
申请日期 |
2010.06.01 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
CHEN, GANG;BURAKOV, DARYA;FANDL, JAMES P. |
分类号 |
C12N15/53;C07K16/00;C12N5/10;C12N9/04;C12P21/00 |
主分类号 |
C12N15/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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