发明名称 |
ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES |
摘要 |
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. |
申请公布号 |
CA2615918(C) |
申请公布日期 |
2013.11.26 |
申请号 |
CA19982615918 |
申请日期 |
1998.02.20 |
申请人 |
GENENTECH, INC. |
发明人 |
HSEI, VANESSA;KOUMENIS, IPHIGENIA;LEONG, STEVEN R.;PRESTA, LEONARD G.;SHAHROKH, ZAHRA;ZAPATA, GERARDO A. |
分类号 |
C07K16/00;A61K39/395;A61K47/48;A61K51/10;A61P29/00;C07K16/24;C07K16/46;C07K17/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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